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Increase in demand for O D negative red cells. Updated guidance published by the National Blood Transfusion Committee

Letter of communication 18 July 2019

Antenatal reference service

RCI offers an antenatal reference service for women whose plasma contains irregular antibodies. The specificity of the antibody is determined or confirmed and the concentration is measured.  All investigations related to the prevention of haemolytic disease of the fetus and newborn (HDFN) are in accordance with the British Society for Haematology (BSH) Guideline for Blood Grouping and Antibody Testing in Pregnancy (2016).

The follow-up investigations are:

  • Monitoring maternal red cell alloantibodies
  • Identification of possible additional antibodies

Additionally the following may be recommended:

  • Red cell phenotypes of the father
  • Fetal genotyping (at IBGRL) using peripheral maternal blood samples