NHSBT clinical guidelines

Red cell transfusion and red cell immunohaematology

  • Managing patients on monoclonal antibody therapies - for hospital transfusion laboratories, transfusion practitioners and haematology clinical teams: essential information
  • Guidelines for the management of urgent red cell transfusion and situations when serological compatibility cannot be assured (INF437/4) (PDF 2359KB)
  • High titre anti-A/B testing of donors within NHSBT (INF178/4)
  • The clinical significance of blood group alloantibodies and the supply of blood for transfusion (SPN214/4)
  • Selecting appropriate blood products for recipients of ABO / Rh mismatched stem cell transplants (SPN215/2)
  • Investigation and clinical management of suspected reactions to IgA (INF486/1.5)
  • Investigation and clinical management of patients with a positive  direct antiglobulin test (DAT) with and without haemolysis (SPN220/3) 
  • Diagnosis and management of T antigen activation (SPN204/1.1) 
  • Red cell unit for intra uterine transfusion and exchange transfusion with positive direct antiglobulin test (DAT) (SPN564/1.1) 


Platelet and white cell transfusion, Histocompatibility and Immunogenetics




Potential blood donors

We accept individuals with genetic haemochromatosis as blood donors once they are in the maintenance phase of the condition with no associated complications. 

  • Agreement form (Word 37.5KB) for potential blood donor with haemochromatosis for use by clinicians. It requires the patient’s signature as confirmation of their agreement. Please return the form to the Clinical Support team at your NHSBT centre.


Management of D Negative female patients with D Positive: Inadvertent red cell or platelet transfusion; Bone grafts; Solid Organ Transplant (SOT) or large volume Fetomaternal Haemorrhage (FMH)