NHSBT clinical guidelines

Red cell transfusion and red cell immunohaematology

  • Managing patients on monoclonal antibody therapies - for hospital transfusion laboratories, transfusion practitioners and haematology clinical teams: essential information
  • Guidelines for the management of urgent red cell transfusion and situations when serological compatibility cannot be assured (INF437/4)
  • High titre anti-A/B testing of donors within NHSBT (INF178/4)
  • The clinical significance of blood group alloantibodies and the supply of blood for transfusion (SPN214/4)
  • Selecting appropriate blood products for recipients of ABO / Rh mismatched stem cell transplants (SPN215/2)
  • Provision of red cell transfusion support for transfusion dependent patients (INF150/5.1)
  • Investigation and clinical management of suspected reactions to IgA (INF486/1.5)
  • Investigation and clinical management of patients with a positive  direct antiglobulin test (DAT) with and without haemolysis (SPN220/3) 
  • Diagnosis and management of T antigen activation (SPN204/1.1) 
  • Red cell unit for intra uterine transfusion and exchange transfusion with positive direct antiglobulin test (DAT) (SPN564/1.1) 


Platelet and white cell transfusion, histocompatibility and immunogenetics

  • Transfusion associated graft versus host disease (INF138/1.1)
  • Guidelines for the management of platelet transfusion refractoriness (INF139/1.1)
  • Transfusion related acute lung injury (TRALI) (INF271/3.4)
  • Post transfusion purpura (INF153/1.1)
  • Clinical guidelines for the use of granulocyte transfusions (INF276/4)
  • Neonatal alloimmune thrombocytopenia (NAIT) (INF272/1.4)
  • Thrombasthenia (POL87/2)/




Potential blood donors

We accept individuals with genetic haemochromatosis as blood donors once they are in the maintenance phase of the condition with no associated complications. 

  • Application form for potential blood donor with haemochromatosis (FRM4058/2) for use by clinicians. It requires the patient’s signature as confirmation of their agreement. Please return the form to the Clinical Support team at your NHSBT centre.
  • Information leaflet for potential blood donors with haemochromatosis (INF935/2)


Management of large RhD positive fetomaternal haemorrhage (FMH), inadvertent transfusion of (RhD+ve) blood or platelets and RhD positive bone grafts in RhD