O D Negative Red Cell Toolkit
Please note that the current International Society of Blood Transfusion terminology for O negative red cells is O D Negative. This terminology will appear in all resources within the Toolkit that were created after June 2016.
Total red blood cell (RBC) usage is falling due to improved surgical techniques and the implementation of Patient Blood Management (PBM) initiatives including the use of alternatives.
However, O D Negative RBC usage remains constant and in some regions of the country it is actually increasing. Stability of the supply chain for universal components such as O D negative RBC remains a challenge for most blood services around the world and NHSBT is working hard to ensure adequate supplies are available when required.
Efforts are primarily focused on improvement of donor marketing to achieve a blood group mix appropriate to clinical demands. Approximately 7 % of the UK population is O D Negative, but current average demand is greater than 12%.
The British Committee for Standards in Haematology (BCSH) guidance on the appropriate use of O D Negative red cells is currently being produced by a writing group led by Dr Megan Rowley. Updates to follow.
As part of their ongoing Action Plan to ensure adequate supplies, the National O D Neg Working Group and NHSBT have launched the following “Save one O D Neg a week” Campaign. This is designed to encourage Trusts to make a difference and consider a range of initiatives to help conserve this precious resource.
To support this campaign an “O D Neg Toolkit” resource has been produced. It is designed to help clinical and laboratory staff in hospitals to promote the safe and appropriate use of O D negative red cells and reduce wastage of this valuable component. This page will be updated as new resources are produced.
'Save one O D Neg a week' campaign - June 2016
- Campaign flyer (PDF) - for distribution to and promotion in all clinical areas using blood components
- Campaign banner (PPT) - for use in educational resources, training presentations, email signatures etc.
- O D neg Good Practice Guidance from London RTC (PDF)
- Top Tips - O D Neg from East of England RTC (PDF)
- O D Neg in Satellite Fridges - Top Tips (PDF)
- O D Neg PowerPoint presentation (PPT) - educational slides for use within Trusts
- NBTC recommendations on the appropriate use of O RhD negative red cells (revised April 2009) (PDF)
- How much is O Neg blood really used by Trauma? (PDF) - poster presented at the Trauma Care Conference 2015, produced by Amanpreet Dhesi, Megan Lawn, Elaine MacRate and Liz Foster.
These graphics are designed to be used alongside appropriate text in presentations and on other educational resources. The graphics are freely available for every Trust. Please acknowledge NHSBT as the author and let us know how you use them.
- O D Neg frequency in UK population and average current demand (PPT)
- Total RBC demand vs O D Neg demand graph (PPT)
- When to use O D Neg – emergency situations (PPT)
- When to use O D Neg – O D Neg patient with anti-D antibodies (PPT)
- When to use O D Neg – Female under 50 years in an emergency (PPT)
- Consider using O D Pos – If >8 O D Neg needed in females >50yrs with no anti-D antibodies and males with no anti-D antibodies (PPT)
- Consider using O D Pos for unknown males (PPT)
- Stock sharing (PPT) – possibility of sharing O D Neg stock within and between Trusts and Independent organisations
- Review O D Neg stock levels to reduce wastage (PPT)
- Give group specific blood asap in an emergency (PPT)
Survey and Audit
- Key findings of 2010 National Comparative Audit of Group O RhD Negative Red Cells (PDF)
- The National Survey on the Use of O RhD Negative Blood 2015 (PDF)
Blood Stocks Management Scheme (BSMS) Tools
- Blood Stocks Management Scheme website
- Using the Issuable Stock Index (ISI) in Blood Stocks Management Scheme. (PDF)
A quick guide for Biomedical Scientists to help monitor stock levels of O RhD negative red cells and other groups.
- Red Cells for Emergency Use - Best Practice from BSMS Regional Roadshow (PDF)
Sharing examples of good practice
Experiences and initiatives from UK Trusts on successfully managing O D Negative stocks, wastage and appropriate use, please contact the individual Trust for more information.
If you would like to share your Trust's good practice please contact your local Patient Blood Management Practitioner or Customer Services Manager.
- The Montefiore Hospital, part of Spire Healthcare (PDF)
- Derby Royal Hospital (PDF)
- Great Ormond Street Hospital (PDF)
- Royal United Hospitals Bath (PDF)
- Guy's and St Thomas' NHS Foundation Trust (PDF)
- St Georges' University Hospital (PDF)