NHSBT Clinical Guidelines

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Samples and donation

We accept individuals with genetic haemochromatosis as blood donors once they are in the maintenance phase of the condition with no associated complications. The form is for use by hospital clinicians referring a patient and requires the patient’s signature as confirmation of their agreement. Please return the completed form to the Clinical Support team at your NHSBT centre.

  • Potential blood donor with haemochromatosis application form (FRM4058/2)
  • Information leaflet for potential blood donors with haemochromatosis (INF935/2)

Red cell transfusion and red cell immunohaematology

  • Managing patients on monoclonal antibody therapies - for hospital transfusion laboratories, transfusion practitioners and Haematology clinical teams: essential information
  • Guidelines for the management of urgent red cell transfusion and situations when serological compatibility cannot be assured (INF437/2)
  • High titre anti-A/B testing of donors within NHSBT (INF178/3)
  • The clinical significance of blood group alloantibodies and the supply of blood for transfusion (SPN214/4)
  • Selecting appropriate blood products for recipients of ABO / Rh mismatched stem cell transplants (SPN215/2)
  • Provision of red cell transfusion support for transfusion dependent patients (INF150/4)
  • Investigation and clinical management of suspected reactions to IgA (INF486/1.4)
  • Investigation and clinical management of patients with a positive  direct antiglobulin test (DAT) with and without haemolysis (SPN220/3) 
  • Diagnosis and management of T antigen activation (SPN204/1.1) 
  • Red cell unit for intra uterine transfusion and exchange transfusion with positive direct antiglobulin test (DAT) (SPN564/1.1)

Platelet and white cell transfusion, histocompatibility and immunogenetics

  • Transfusion associated graft versus host disease (INF138/1.1)
  • Guidelines for the management of platelet transfusion refractoriness (INF139/1.1)
  • Transfusion related acute lung injury (TRALI) (INF271/3.4)
  • Post transfusion purpura (INF153/1.1)
  • Clinical guidelines for the use of granulocyte transfusions (INF276/4)
  • Neonatal alloimmune thrombocytopenia (NAIT) (INF272/1.4)
  • Thrombasthenia (POL87/2)


  • Management of large RhD positive fetomaternal haemorrhage (FMH), inadvertent transfusion of (RhD positive) blood or platelets and RhD positive bone grafts in RhD (SPN216/6)