InCiTe Study
Case Control Study of Intra-Cranial Haemorrhage in Thrombocytopenic Haematology Patients
What is it?
A national case-control study of intra-cranial haemorrhage in the UK, over a two year period, in adult haematology patients who are receiving, are about to receive or have just received myeloablative chemotherapy or a stem cell transplant with curative intent.
This study will include all severities of intra-cranial haemorrhage from small asymptomatic haemorrhages, identified only radiologically, to large fatal haemorrhages.
Why is this study important?
- Intra-cranial haemorrhage is a serious but rare complication that occurs in patients with haematological malignancies.
- If it occurs it can have devastating consequences (death or major morbidity).
- It is unknown why some patients bleed and others don't.
- Risk of significant bleeding is poorly correlated with the platelet count.
Aims of the study
- To identify risk factors for intra-cranial haemorrhage.
- To use this information to guide management of patients in the future:
- decrease a patient's exposure to prophylactic platelet transfusions if they have a low risk of bleeding
- develop intensified management strategies for patients with a high risk of bleeding.
Study protocol (pdf 72KB)
Inclusion criteria for controls
Inclusion criteria for cases
Newsletter
March 2012 (pdf 60KB)
December 2011 (pdf 60KB)
September 2011 (pdf 60KB)
Contact details
Clinical Data Manager
Tania.Reed@nhsbt.nhs.uk
Coordinator
Lise.Estcourt@nhsbt.nhs.uk
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