InCite Study

Case Control Study of Intra-Cranial Haemorrhage in Thrombocytopenic Haematology Patients

This study has now closed to recruitment (closed to recruitment June 2015)

What is it?

A national case-control study of intra-cranial haemorrhage in the UK, over a four year period (2011 to 2015), in adult haematology patients who were:

  • receiving
  • about to receive or
  • just received myeloablative chemotherapy or a stem cell transplant. 

This study included all severities of intra-cranial haemorrhage from small asymptomatic haemorrhages, identified only radiologically, to large fatal haemorrhages.

Why is this study important?

  • Intra-cranial haemorrhage is a serious but rare complication that occurs in patients with haematological malignancies
  • If it occurs it can have devastating consequences (death or major morbidity)
  • It is unknown why some patients bleed and others don't
  • Risk of significant bleeding is poorly correlated with the platelet count.

Aims of the study

  • To identify risk factors for intra-cranial haemorrhage
  • To use this information to guide management of patients in the future:
    • decrease a patient's exposure to prophylactic platelet transfusions if they have a low risk of bleeding
    • develop intensified management strategies for patients with a high risk of bleeding.


InCite newsletter

2011 to 2013 newsletters may be obtained from the Study Co-ordinator 

 

Contacts

Chief Investigator 
lise.estcourt@nhsbt.nhs.uk                                        

Study Co-ordinator
chloe.holt@nhsbt.nhs.uk